MOTS-C is a naturally occurring peptide derived from mitochondrial DNA, involved in regulating metabolic functions and cellular energy.
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MOTS-C is a mitochondrial-derived peptide encoded by the mitochondrial genome, specifically within the mitochondrial open reading frame of the mtDNA. This 16 amino acid peptide plays a crucial role in regulating metabolic processes. Specifically within skeletal muscle and other tissues involved in energy production and expenditure. MOTS-C contributes to maintaining glucose homeostasis and improving insulin resistance. This makes it a potential therapeutic target for conditions such as hyperglycemia and obesity.
Additionally, MOTS-C interacts with signaling pathways to mitigate oxidative stress and reduce reactive oxygen species. These play a key role in cellular senescence and the aging process. Current Denmark research highlights its impact on muscle metabolism and its ability to enhance physical performance. It does this by targeting specific pathways with minimal side effects. These findings suggest that MOTS-C holds great promise for addressing issues related to mitochondrial function and overall human health.
MOTS-c is a peptide encoded by the mitochondrial 12S rRNA gene that regulates stress adaptation, energy metabolism, and aging-related processes. They are encoded by mitochondrial DNA and influence energy production and use. These peptides activate AMP-activated protein kinase (AMPK), an enzyme that plays a key role in maintaining energy balance. This activation improves glucose metabolism and boosts insulin sensitivity. MOTS-c peptides also help cells respond to stress, improving mitochondrial function and overall metabolic health. Because of these benefits, they are being explored as a potential treatment for metabolic issues like obesity and type 2 diabetes.
Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.64 f/mol
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
View our MOTS-C High-Performance Liquid Chromatography (HPLC) Certificate here.
Buy MOTS-C Nasal Spray
Buy MOTS-C nasal spray Denmark for clinical research from Direct Sarms, available in 15ml and 30ml bottles.
Buy MOTS-C Peptide Vial
Buy MOTS-C Peptide Vial 10mg Denmark for research from Direct Sarms. It is also available as a convenient kit, complete with bacteriostatic water and syringes, this option streamlines the peptide reconstitution process, making it easier and more efficient for researchers.
What is mitochondria?
Mitochondria are membrane-bound organelles found in most eukaryotic cells. They are often referred to as the “powerhouses of the cell.” They are responsible for generating the majority of the cell’s adenosine triphosphate (ATP), which is the primary source of energy for cellular processes.
Apart from energy production, mitochondria also play a vital role in cell signaling, apoptosis (programmed cell death), and regulating cellular metabolism. Their proper function is crucial for maintaining overall cellular health and energy balance.
What are the potential benefits of MOTS-c?
Denmark Research indicates that mitochondrial peptides, cincluding MOTS-c may enhance energy levels, promote healthy aging, improve physical performance, and regulate metabolic disorders such as obesity and insulin resistance.
Is MOTS-c naturally occurring in the body?
Yes, MOTS-c is a naturally occurring peptide produced by mitochondria. It functions as a signaling molecule to support metabolic processes and cellular health.
Are there any known side effects of MOTS-c?
Although MOTS-c is a promising peptide, its supplementation requires more extensive clinical trials. Currently, its side effects are not well-documented, and it should be used under professional guidance.
Who can benefit from MOTS-c?
MOTS-c may be beneficial for individuals dealing with metabolic challenges, aging concerns, or those seeking to improve overall vitality. However, medical advice should be sought before starting any treatment.
Is MOTS-c approved by the FDA?
Currently, MOTS-c is not approved by the United States Food and Drug Administration (FDA) for medical use. Research on MOTS-c is still in its early stages, and while preliminary studies suggest potential benefits, further clinical trials are needed to establish its safety, efficacy, and regulatory approval.
For more information, explore our latest blog posts dedicated to MOTS-C peptides.
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Buy MOTS-c peptides Denmark from Direct Sarms. Available in various formulations to support both laboratory and clinical research. Options include non-invasive nasal sprays, vials containing lyophilized powder for subcutaneous injections, and pre-mixed pens with peptides blended with bacteriostatic water in sterilized cartridges.
When you buy MOTS-c, it’s important to choose reliable suppliers like Direct Sarms Denmark to ensure consistent quality and purity. High-quality MOTS-c is crucial for accurate research results, especially given its role in studying metabolic regulation and cellular processes.
[1] Yuejun Zheng, Zilin Wei, and Tianhui Wang (2023) MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation – Frontiers in Endocrinology (Lausanne), 2023 Jan 25, Volume 14, Page 1120533.
[2] Joseph C. Reynolds, Rochelle W. Lai, Jonathan S. T. Woodhead, James H. Joly, et al (2021) MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis – Nature Communications, 20 January 2021, Volume 12, Article number: 470.
[3] Wei Wan, Lieliang Zhang, Yue Lin, Xiuqing Rao, et al (2023) Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging – Journal of Translational Medicine, 20 January 2023, volume 21, Article number: 36.
[4] Xuejie Yi, Guangxuan Hu, Yang Yang, Jing Li, et al (2023) Role of MOTS-c in the regulation of bone metabolism – Frontiers in Physiology, 02 May 2023, Section: Exercise Physiology, Volume 14.
[5] Huanyu Lu, Linni Fan, Wenli Zhang, Guo Chen, et al (2024) The mitochondrial genome-encoded peptide MOTS-c interacts with Bcl-2 to alleviate nonalcoholic steatohepatitis progression – Cell Reports, Volume 43, Issue 1, 23 January 2024, 113587.
[6] Jakub Bień, Ewa Pruszyńska-Oszmałek, Paweł Kołodziejski, Natalia Leciejewska, et al (2024) MOTS-c regulates pancreatic alpha and beta cell functions in vitro – Springer Nature Link, 02 March 2024, Volume 161, pages 449–460.
[7] Sahar Parseh, Saeid Shakerian, Mohammad Reza Tabandeh, and Abdolhamid Habibi (2024) An 8-Week study on the effects of high and Moderate-Intensity interval exercises on mitochondrial MOTS-C changes and their relation to metabolic markers in male diabetic sand rats – Diabetes Research and Clinical Practice, Volume 212, June 2024, 111656.
[8] Peng Zhong, Jianye Peng, Yewen Hu, Jun Zhang, and Caijie Shen (2022) Mitochondrial derived peptide MOTS-c prevents the development of heart failure under pressure overload conditions in mice – Journal of Cellular and Molecular Medicine, 2022 Nov, Volume 26 (Issue 21), Pages 5369-5378.
[9] Manda Wang,Gangqiang Wang, Xiaoli Pang, Jiacheng Ma, et al (2023) MOTS-c repairs myocardial damage by inhibiting the CCN1/ERK1/2/EGR1 pathway in diabetic rats – Front. Nutr., 04 January 2023, Sec. Nutrition and Metabolism, Volume 9 – 2022.
[10] Qing Qin, Silvia Delrio, Junxiang Wan, R Jay Widmer, et al (2018) Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction – International Journal of Cardiology, 2018 Mar 1, Volume 254, Pages 23-27.
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